Project: Cardioprotective mechanism of cold acclimation
Research group: Žurmanova
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Novel cardioprotective strategies are needed that can stimulate endogenous signalling pathways to protect the heart from myocardial infarction. Recently we newly established that appropriate regimen of cold acclimation (CA) may provide a promising approach for improving myocardial resistance to ischemia/reperfusion (I/R) injury without negative side effects also for a clinical use (Tibenská et al. under revision). Our further data suggests important but diverse role of β-adrenergic pathways in the mechanism of cold elicited cardioprotection. However, direct confirmation of our findings in in vivo model is needed. Therefore we are searching for highly motivated talented student who would like to test the effects selected inhibitors of downstream kinases of adrenergic pathways (protein kinase A, protein kinase B, protein kinase Cε and protein kinase G) using CA rat model of myocardial infarction in vivo. Another challenge of the applicant is to adopt the method of myocardial infarction in vivo from rat to mice. This important step would enormously increase impact of our research by using transgenic mice models for CA. All equipment for rat and mice models is available. The applicant is supposed to be excellent student with sufficient experiences in surgery or great interest in myocardial signalling and surgery.
Deadline is closed